Lantern Pharma Inc. LTRN
Lantern Pharma Inc. (Nasdaq: LTRN) is an oncology drug developer. Its lead program, LP-300 (Harmonic trial), is in Phase 2 for never-smoker non-small cell lung cancer (NSCLC), in combination with chemotherapy; focus on EGFR exon 21 L858R.
Upcoming catalysts
No catalyst is dated to the next 30 days or to an FDA action date.
Pipeline
| Program | Indication | Modality | Stage |
|---|---|---|---|
| LP-300 (Harmonic) | never-smoker NSCLC | small molecule | Phase 2 |
| LP-184 (STAR-001 in CNS) | solid tumors incl. TNBC, NSCLC (KEAP1/STK11), GBM | small molecule | Phase 1 |
| LP-284 | hematological cancers | small molecule | Phase 1 |
| LP-100 | prostate cancer in combination with PARP inhibitors | small molecule | Pre-clinical |
| ADC program (cryptophycin payload) | solid tumors | biologic-other | Pre-clinical |
Recent results and decisions
- Aug 14, 2026positive Emerging Phase 2 data (May 11, 2026 cutoff): median PFS 8.9 months in L858R patients completing six cycles (n=9) vs 8.4 months in overall L858R cohort (n=16); HR 0.37 in L858R subgroup; small exploratory cohorts.
Median progression-free survival reached 8.9 months among L858R patients who completed six cycles of LP-300 (n=9, of whom three had not progressed at the time of analysis), compared with 8.4 months across the overall L858R cohort (n=16).
Filing - Nov 13, 2025positive Phase 1a (63 patients) achieved all primary endpoints; 48% clinical benefit rate in evaluable patients at or above the therapeutic dose threshold; RP2D 0.39 mg/kg.
The trial demonstrated clinical benefit in 48% of evaluable cancer patients treated at or above the therapeutic dose threshold.
Filing
For subscribers
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