CalciMedica, Inc. CALC
CalciMedica, Inc. (Nasdaq: CALC) is a GI/hepatology drug developer. Its lead program, Auxora (zegocractin), is in Phase 2 for acute pancreatitis (with SIRS); also AKI with AHRF. Its next catalyst on record is Auxora: Phase 1b proof-of-concept data in PAH (2027).
Upcoming catalysts
No catalyst is dated to the next 30 days or to an FDA action date.
Next further out: Auxora — Phase 1b proof-of-concept data in PAH (2027). 2 catalysts on record beyond the next 30 days; subscribers see each with its filing sentence.
Pipeline
| Program | Indication | Modality | Stage |
|---|---|---|---|
| Auxora (zegocractin) | acute pancreatitis | small molecule | Phase 2 |
| Auxora (zegocractin) | acute kidney injury with acute hypoxemic respiratory failure (KOURAGE) | small molecule | Phase 2 |
| Auxora (zegocractin) | pulmonary arterial hypertension | small molecule | Phase 1 |
| CM5480 | pulmonary hypertension (PAH, CpcPH-HFpEF) | small molecule | Pre-clinical |
Recent results and decisions
- Jan 28, 2026discontinued CalciMedica discontinued the Phase 2 KOURAGE trial after the IDMC identified a safety concern at a prescheduled interim review; no deaths assessed as drug-related.
During a prescheduled interim data review, the IDMC identified a safety concern that, in its view, warrants reevaluation of the study design, particularly with respect to patient enrollment criteria.
Filing
For subscribers
- Cash runway against each catalyst, with the company's own runway statement
- Track record: every Phase 3 readout, FDA decision and guidance slip since 2014
- Expected move for each dated catalyst, from comparable past events
- Phase 2 evidence behind each Phase 3 readout
- Companies on the same target or class
- Full catalyst list with filing sentences, deals, registered trials, Excel export
Other phase 2 GI/hepatology companies
The free Monday brief
Last week's readouts and FDA decisions and the dated catalysts in the week ahead, each with its filing sentence.